PuraMatrix® PuraStat®

PuraMatrix® is an ideal synthetic, transparent, biocompatible, and bioresorbable material situated at the intersection of chemical engineering and biology.

PuraMatrix® in vivo extracellular matrix has wide-ranging laboratory and clinical applications, including cell culture, drug delivery, accelerated cartilage and bone growth, and regeneration of CNS, soft tissue, and cardiac muscle.


Product Advantages

The advantages of using PuraMatrix® stem from the product’s simple, customizable composition: three common amino acids coupled to generate a 16-mer which is formulated into a fully transparent, ready-to-use hydrogel. PuraMatrix®‘s advantages have been validated by more than 200 publications from independent academic labs, customers, collaborators, and 3-D Matrix’s scientific founders.


Synthetic Nanofiber

In both scale and function, PuraMatrix® resembles natural collagen, the most abundant protein in nature. Collagen and other similar proteins provide structural integrity to the extracellular matrix (ECM) as in vivo scaffolds for cell attachment, migration and tissue organization. Human and animal derived collagen and similar proteins present risk of infection and immune response due to their biogenic origins. As a fully synthetic, non-animal derived extracellular matrix, PuraMatrix® removes any risks associated with biogenic sources. Additionally, the ability to produce PuraMatrix®peptide hydrogel by strictly controlled and validated ISO-certified manufacturing techniques without the use of human or animal sources, or of recombination, ensures a pure, defined, always reproducible, high quality product.


Biocompatible Short Term Resorbable

PuraMatrix® has passed a rigorous suite of biocompatibility and toxicity tests for medical devices, demonstrating complete resorption in less than 30 days – without problematic immune reactions or toxic breakdown products. Short-term resorbability and function as a provisional biomaterial not only contribute to enhanced usability but also mitigate concerns which plague other resorbable biomaterials (breakdown of products, foreign body response, scarring and post-operative pain). A number of animal studies by both 3-D Matrix and independent clinical researchers have demonstrated these advantages, resulting in a strong body of published literature.


Injectable Delivery

PuraMatrix® can be injected through fine gauge needles and catheters. PuraMatrix®gels after injection into tissue, trapping therapeutics and preventing back-leakage of injectate, thus retaining therapeutics in a tissue or defect for a longer period. The nanofiber assembly can retain and release protein therapeutics (BMP, PDFG, VEGF, etc.), drugs and cells in a controlled manner for up to 10 days, depending on the therapeutic and dynamics of the particular tissue. Together, these features serve unmet needs across a range of biomaterial applications while complementing biologics, therapeutics, medical devices and surgical procedures. Functional delivery can mean the difference between success and failure, especially for those therapies with demonstrated effectiveness in vitro.


Allograft and Autograft Extender

Many opportunities exist to combine PuraMatrix® with allograft biomaterials and autograft tissue. Not only does PuraMatrix® serve as a synthetic extracellular matrix, but it also acts as an injectable extender, allowing superior surgical handling and delivery while decreasing the amount of allograft or autograft needed per procedure.


Find out the most recent developments at 3-D Matrix

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Review the strong body of literature utilizing PuraMatrix®

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This website is not intended for French healthcare professionals.

If you are a French healthcare professional, please contact your sales representative for any information.

Ce site internet n’est pas destiné aux professionnels de santé française.

Si vous êtes un professionnel de santé français, merci de contacter votre contact local pour toutes demandes d’informations.