PuraMatrix® is the first commercial synthetic extracellular matrix (ECM) scaffold, enabling cells to be cultured in carefully controlled microenvironments for life science research, pharmaceutical drug discovery and bioproduction. PuraMatrix® enhances valuable and expensive cell assays that predict proper drug interactions and metabolism. In particular, PuraMatrix® has improved cell assays in which one or more types of cells form complex structures (such as spheroids, networks, synapses, vascularization). The result is improved models for in vivo and in vitro research and testing, increasing predictability and reducing the cost of drug discovery research. Click here to review PuraMatrix® Guidelines for Use.
PuraMatrix® is a synthetic peptide hydrogel scaffold that can be used to create tailored 3-dimensional micro-environments for a variety of clinical and laboratory applications. The peptide hydrogel has three main characteristics. First, it can be used as a 3-dimensional matrix for cell growth and for tissue regeneration. Second, the 3-dimensional matrix can be used for controlled drug release applications. It stores molecules from small to very large sizes (proteins, antibodies) and releases them continually over time. Third, the 3-dimensional matrix binds to tissue and can therefore be used to seal leaks of physiologic fluids from organs, including bleeding.
PuraMatrix® Peptide Hydrogel consists of standard amino acids (typically 0.5 – 3% w/v), the remainder being water (99.5% or less). Under physiological conditions, the synthetic peptide component self-assembles into a 3-dimensional hydrogel that exhibits a nanometer scale fibrous structure similar to native extracellular matrix. The hydrogel is readily formed in vivo or various molds, and in a culture dish, plate, or cell culture insert. PuraMatrix® is injectable through fine gauge needles and appropriate for in vivo tissue fill, drug delivery, cell delivery, and implant coatings.