Publications

PuraMatrix® has been used in many different clinical and research applications for more than fifteen years. Its versatility is demonstrated through the large body of literature that covers its broad applications.

Cardiovascular

Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction.
Biochem Biophys Res Commun. 2012 Jul 20;424(1):105-11. Epub 2012 Jun 22.
Guo HD, Cui GH, Yang JJ, Wang C, Zhu J, Zhang LS, Jiang J, Shao SJ.
Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Copyright © 2012 Elsevier Inc. All rights reserved.

Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8155-60. Epub 2006 May 12.
Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

The enhancement of mature vessel formation and cardiac function in infarcted hearts using dual growth factor delivery with self-assembling peptides.
Biomaterials. 2011 Sep;32(26):6080-8. Epub 2011 Jun 1.
Kim JH, Jung Y, Kim SH, Sun K, Choi J, Kim HC, Park Y, Kim SH.
Biomaterials Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Substrates for cardiovascular tissue engineering.
Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):221-41. Epub 2011 Jan 25.
Bouten CV, Dankers PY, Driessen-Mol A, Pedron S, Brizard AM, Baaijens FP.
Soft Tissue Biomechanics and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Copyright © 2011 Elsevier B.V. All rights reserved.

Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.
J Tissue Eng Regen Med. 2011 Apr;5(4):e74-86. doi: 10.1002/term.389. Epub 2011 Jan 10.
Allen P, Melero-Martin J, Bischoff J.
Vascular Biology Program, Children’s Hospital, Boston, MA 02115, USA.
Copyright © 2011 John Wiley & Sons, Ltd.

Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction.
J Mol Cell Cardiol. 2010 Dec;49(6):972-83. Epub 2010 Sep 24.
Tokunaga M, Liu ML, Nagai T, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Wang P, Naito AT, Komuro I.
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Transplantation of marrow-derived cardiac stem cells carried in designer self-assembling peptide nanofibers improves cardiac function after myocardial infarction.
Biochem Biophys Res Commun. 2010 Aug 13;399(1):42-8. Epub 2010 Jul 15.
Guo HD, Cui GH, Wang HJ, Tan YZ.
Department of Anatomy and Histology and Embryology, Shanghai Medical School of Fudan University, China.
2010 Elsevier Inc. All rights reserved.

Co-culture induces alignment in engineered cardiac constructs via MMP-2 expression.
Biochem Biophys Res Commun. 2008 Aug 29;373(3):360-5. Epub 2008 Jun 16.
Nichol JW, Engelmayr GC Jr, Cheng M, Freed LE.
Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25-330, Cambridge, MA 02139, USA.

Stem-cell therapy for cardiac disease.
Nature 451, 937-942 (21 February 2008) |doi:10.1038/nature06800; Published online 20 February 2008
Segers VFM, Lee RT
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Partners Research Facility, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.
© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction.
Circulation. 2007 Oct 9;116(15):1683-92. Epub 2007 Sep 17.
Segers VF, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass, USA.

Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity.
Circulation. 2006 Aug 15;114(7):637-44. Epub 2006 Aug 7.
Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Mass., USA.

Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers.
J Clin Invest. 2006 Jan;116(1):237-48. Epub 2005 Dec 15.
Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Custom design of the cardiac microenvironment with biomaterials.
Circ Res. 2005 Jul 8;97(1):8-15.
Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT.
Cardiovascular Division , Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.

Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells.
Circulation. 2005 Feb 1;111(4):442-50.
Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.

Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration.
Circulation. 2004 Aug 24;110(8):962-8. Epub 2004 Aug 9.
Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, Lee RT.
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.

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